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Similarly, AMD is closely linked to Aβ deposition beneath the retinal pigment epithelium (Ding et al., 2011), and glaucomatous degeneration of retinal ganglion cells (RGCs) is associated with p-tau (Liu et al., 2018)

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ISC proliferation depends on ligands of the WNT signaling pathway and their R-spondin cofactors, with a gradient of WNT signaling strongest at the crypt base and weakest at the villus tip (17, 18)