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Furthermore, single-cell sequencing revealed that compared to physiological scars, keloidal scars contained an expanded “mesenchymal” fibroblast population overexpressing many of the same genes as CD26 + and other fibrogenic fibroblasts [secreted frizzled related protein 4, serine protease 23, transforming growth factor–β1 (TGF-β1), and periostin] (16)

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