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[DOI] [PMC free article] [PubMed] [Google Scholar] 106.Gouazé V., Mirault M.-É., Carpentier S., Salvayre R., Levade T., Andrieu-Abadie N

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Prolonged exposure to irritants such as tobacco smoke leads to a sustained increase in oxidative stress in the lungs of COPD patients, which in turn inhibits the function of the nuclear factor erythroid 2-related factor 2 (Nrf2) pathway and weakens the body’s antioxidant defences, leading to further damage to alveolar structure, increased airway remodelling, and inflammatory responses, thus driving the pathological progression of the disease [7]