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The affinity for the ETGE motif is 200-fold greater than that for the DLG motif, and the ETGE motif is thought to function as the “hinge”, whereas the DLG motif functions as the “latch”, positioning the NRF2 lysine-rich helix for ubiquitination (McMahon et al., 2006, Tong et al., 2006)
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