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The initial condition was set at 99% B, linearly decreasing to 70% B from 0.5 min to 4.0 min, and 1% B from 4.0 min to 6.5 min, and was then maintained at 1% B for 2.5 min

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607 In functional studies, astrocytes differentiated from stem cells obtained from familial AD showed aberrant Ca 2+ signalling, 608,609 increased production of reactive oxygen species, reduced lactate supply, compromised neuroprotection, and inability to support neurones in co-cultures