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, the healing of other epithelia) may be combined in the simultaneous healing of different tissues, such as the simultaneous healing of fistula defects and the closing of fistulas[1]

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The adaptive activation of Nrf2 leads to increased expression of Nrf2-controlled genes that encode detoxification enzymes (NQO1), antioxidant enzymes (GPx2, Srx1), and enzymes for the synthesis of low-molecular-weight antioxidants (GSH, bilirubin), all of which suppress CS-induced ROS production and oxidative damage (see Supplemental Table 1 and accompanying references)