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In addition, SLC7A11 and GCL have also been shown to be regulated by Nrf2(Kang et al., 2021)
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However, a recent study suggested that, rather than inducing R-loop formation, the transcriptional burst triggered by oncogenic RAS leads to H3K27me3- and HP1-associated chromatin compaction, thereby resulting in replication fork stalling and cell death 11
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