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Iron metabolism and ferroptosis in human health and disease - PMC

Carboxylesterase 2 prevents liver steatosis by modulating lipolysis, endoplasmic reticulum stress, and lipogenesis and is regulated by hepatocyte nuclear factor 4 alpha in mice

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Effects on brain-specific endpoints, such as long-term cognitive decline, amyloid burden, and tau pathology, have not been sufficiently studied to determine safe dose ranges