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It has also been suggested that climate models may not be capable of capturing these midlatitude circulation responses 37,38,39,40,41 and that cold extremes may increase in frequency 26,32 , or at least, not decrease as fast as models predict 32,39,41,42

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Nevertheless, other studies have shown that activation of autophagy presented beneficial effects that facilitated lapatinib to overcome drug resistance and increase its toxicity in tumor cells [132]