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Since the protective action of melatonin was accompanied by increased mucosal blood flow and could be attenuated by pretreatment with COX or NO inhibitors such as indomethacin or L-NAA, respectively, and by pretreatment with capsaicin in neurotoxic dose (125 mg/kg) to inactivate the sensory nerves (45), we propose that melatonin protects esophageal mucosa by increasing the mucosal blood flow due to the enhancement of prostaglandin, NO and CGRP release in the mucosa

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