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The addition of L-GSH to spike protein and untreated PBMCs increased total intracellular GSH, decreased IL-6, TGF-beta, and TNF-alpha levels, decreased oxidative stress, as demonstrated through MDA, and decreased fibrin clot formation, as detected by fluorescence microscopy

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Specifically, PRDX1-OE attenuated the progression of CIA and reduced the proportion of plasma cells along with antibody production