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The histological characteristics of IC, including the thinning and erosion of the bladder epithelium, along with heightened infiltration by mast cells, suggest that the condition may stem from the compromised regenerative capacity of the bladder’s epithelial cells, coupled with anomalies in immune system functioning (Slobodov et al., 2004)

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[DOI] [PMC free article] [PubMed] [Google Scholar] 213.Shetty S, Kusminski CM, Scherer PE