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By inhibiting P-gp, these agents enhance cellular drug retention but may inadvertently increase systemic drug concentrations, posing toxicity risks for narrow-therapeutic-index medications (e.g., chemotherapeutics, cardiovascular drugs) (32, 88–90)

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Vitamin D and calcium — the target is usually 1,200–1,500 mg of elemental calcium per day from diet and supplements combined, alongside vitamin D (commonly 800–2,000 IU/day, adjusted according to blood levels)