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Additionally, the regulation of ferroptosis involves other critical systems, such as the tetrahydrobiopterin (BH4)-GCH1 system (55) and the dihydrofolate reductase-reduced coenzyme Q (DHFR-CoQH 2 ) system (56, 57)
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It was found that SP had no impact on the mRNA transcription of Keap1 , whereas the transcription levels of Nrf2 and Homx1 were significantly elevated (Supplementary Fig
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