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(4) Homocysteine Remethylation to Close the Methionine Cycle The reconversion of homocysteine to methionine is driven by methionine synthase, which transfers a methyl group from 5-methyltetrahydrofolate to homocysteine

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In this section, we will review the most used and promising tools for BBBP assessment and HT prediction, each of which has its own advantages and disadvantages (Table 1)