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A comprehensive review in Nature Reviews Disease Primers described the global prevalence of B12 deficiency and emphasized the importance of recognizing at-risk populations, including the elderly, vegetarians and vegans, patients with autoimmune conditions, and those with GI disease (Green et al., Nat Rev Dis Primers , 2017)

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Patients who also implement a caloric deficit of at least 500 kcal/day and 150 minutes of moderate-intensity aerobic exercise per week (per the 2023 AHA/ACC obesity management guidelines) [10] cannot attribute observed fat loss to the peptide alone without controlled conditions