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This problem has now been overcome by using purified intrinsic factor which does not react with vitamin B12 analogs as the binder in the immune-enzymatic assays (Klee, 2000)
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Although absorption in the blood of the 2 B 12 forms was similar, the study found that MeCbl supplementation caused 13% more cobalamin to be stored in the liver than did CNCbl supplementation.7 Chalmers8 reviewed the results of 3 human studies that also found lower tissue retention of B 12 as a result of supplementation with CNCbl rather than OHCbl, MeCbl, or AdCbl, together with increased urinary excretion of CNCbl
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