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One study used mB12 intramuscularly at 1 mg once per week in 2 children and 10 mg of oral hB12 in another child [51]
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Similarly, in cells under oxidative stress conditions, activated NRF2 can enhance the expression of MFN1 and MFN2 while degrading DRP2 through the proteasomal pathway, leading to mitochondrial hyperfusion, which temporarily protects cells and alleviates oxidative stress as well as inhibits ferroptosis [109]
