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Vitamin B12 and Metformin The diabetes medicine, metformin, interferes with B12 absorption in the intestine by impeding the calcium-dependent intake mechanism

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However, in patients treated with diclofenac and glucocorticoids, the risk of peptic ulcer and gastrointestinal bleeding may increase, so special attention should be given in case of prolonged treatment, even in the absence of serious gastrointestinal symptoms