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🧪 Glutathione Depletion Pathways 1. Precursor Depletion - Key bottleneck: Cysteine availability. - Source: Diet or hepatic transsulfuration ( methionine → homocysteine → cysteine). - Failure mode: Downregulation of cystathionine γ‑lyase (CSE) during
Its taxonomic status has changed over time and remains controversial [5]
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Nature , 474 (7351), 403–406
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