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A 2024 meta-analysis (pooled n = 2,350) of 33 randomized controlled trials concluded that Coenzyme Q10 supplementation significantly reduced mortality (relative risk 0.64) and hospitalizations for heart failure (relative risk 0.50), while improving left ventricular ejection fraction, B-type natriuretic peptide levels, and 6-min walk distance (Xu et al., 2024)
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These results confirm that the rational design of CoQ 10 analogues as novel antioxidants is possible and efficient
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