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The Mrp proteins mediate not only GSH efflux, but they also export oxidized glutathione derivatives (e.g., glutathione disulfide (GSSG), S -nitrosoglutathione (GS-NO), and glutathione-metal complexes), as well as other glutathione S -conjugates
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Several studies have shown that free-radical-mediated neuronal dysregulation plays a key role in the pathophysiology of psychiatric diseases by increased SOD activity levels, such as in schizophrenia 42
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