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IFN-γ can also promote expansion ( Tbx 21, that contributes to the expression of IFN-γ, PRF and GZMB in cytotoxic CD8+ T cells ( +/− Tbx 21 −/− mice are defective in IFN-γ induction and impaired in cytolytic function in CD8+ T cells ( Epigenetics DNA Methylation DNA methylation is an epigenetic process that involves the addition of a methyl group to the 5th carbon in cytosine residues of cytosine-guanine (CpG) dinucleotides, to produce 5-methylcytosine residues ( de novo methylation during embryonic development
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