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Moreover, in macrophages, the pro-inflammatory M1 marker’s morphology and genes (associated with pro-inflammatory cytokine production) are suppressed by sulforaphane, while it promotes the M2 marker genes associated with the anti-inflammatory mechanism [73,77,85,99]
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Melasma can appear when a woman’s hormones change, whether through pregnancy, oral contraceptives, or hormone replacement therapy after menopause
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