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Several MTHFR gene polymorphisms have been described, and some of them seem to affect the individual susceptibility to a number of pathological conditions associated with homocysteine disorders, like myocardial infarction, stroke, neurodegenerative diseases, autoimmune diseases, cancer, diabetes, birth defects and kidney disease [73]

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Second, NNMT depletes that universal methyl donor, SAM, which is essential for DNA methylation, neurotransmitter production, and other indispensable biological processes