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Since creatinine is a byproduct of muscle metabolism, individuals with greater muscle mass, those who engage in more physical activity, or those generally in better health produce more creatinine than people with lower muscle mass, physical activity levels, and poorer overall health

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Regulation of Cyclic AMP Response Element-Binding Protein (CREB) Phosphorylation by Acute and Chronic Morphine in the Rat Locus Coeruleus