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6A–D), After the ACN intervention, 2-Oxocarboxylic acid metabolism, Biosynthesis of amino acids, Nucleotide metabolism, Biosynthesis of unsaturated fatty acids, Purine metabolism, Glycine, Serine and threonine metabolism Abnormalities affected the steroid metabolism pathway, the metabolic pathways of cysteine and methionine, Thus causing a series of reproductive hormone secretion disorders, oxidative stress, Adherence responses such as chronic inflammation and gut dysbiosis