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Other anamolies of the PDC include autoantibodies leading to paediatric biliary cirrhosis [47].Additionally, the aberrant down-regulation of pyruvate dehydrogenase complex activity by reversible phosphorylation has been shown to be contributory to hyperglycemic states observed in type-2 diabetes [25], increasing the chances of pyruvate dehydrogenase complex as a therapeutic target for a 150 million people affliction i.e

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evaluated the effect of the oral Cu–protein-binding molecule WTX101 (the bis-choline salt of TTM) and found that WTX101 rapidly improved Cu homeostasis, leading to the improved neurological outcome and stabilizing liver function 90 (Table 1)