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220 Busulfan clearance for patients older than 18 years averages 2.64 to 2.9 mL/min/kg, whereas for children aged 2 to 14 clearance averages 4.4 to 4.5 mL/min/kg, and for children aged 3 or younger, it is 6.8 to 8.4 mL/min/kg

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This design creates a molecule that is 2-3 times more potent than native IGF-1 in driving anabolism and nitrogen retention in research models