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Ferrer-Sueta and colleagues [104] give the example of Cys51 on human peroxiredoxin 2 (Prx-II), which may be oxidised much faster (k = 1 × 10 8 M −1 .s −1 ) than free cysteine (26 M −1 .s −1 ) by H 2 O 2

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Blood–brain barrier dysfunction in aging induces hyperactivation of TGFβ signaling and chronic yet reversible neural dysfunction