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8.3 Biomarker identification Some biomarkers of ferroptosis, such as TFRC, ACSL4, prostate-independent peroxidase synthetase 2 (PTGS2)and hyperoxidized PRDX3, are measured at the mRNA or protein level to monitor the ferroptosis response (10, 107–109)

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Upon IκB degradation, NF-κB is released and translocates into the nucleus, where it recruits p300, which in complex with cAMP response element-binding protein acetylates RelA/p65, thereby activating NF-κB transcription and enhancing the expression of downstream pro-inflammatory genes (Lawrence 2009)