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D-Nle-Tyr-Ile- NH-(CH 2 )5-CONH2 is not expected to be highly bound to plasma proteins according to quantitative structure-activity relationship (QSAR) modeling (discussed below) and since total recovery from serum was greater than 35 %

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The first limitation is that we demonstrated oxidative stress marker concentration changes in peripheral blood of ASD children, but how much the peripheral measurements reflect oxidative stress activity within the brain is unknown