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It was originally speculated that the peptide bound in these receptors and increased the rate of metabolism in fat cells, shifting them from a storage mode to a usage mode

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A broader 2021 review by Liu, Deng, Zhu, and colleagues in BioMed Research International synthesized the literature on NNMT in obesity and type 2 diabetes, concluding that elevated NNMT activity is a consistent feature of both conditions across human and animal studies