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The therapeutic effect refers to the eradication or improvement of the underlying disease, and/or the eradication or improvement of one or more symptoms associated with the underlying disease, so that the patient reports an improvement in sensation or symptoms, although the patient will still be able to afflicted by underlying disease

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This interaction promotes the dissociation of the KEAP1-NRF2 complex, preventing NRF2 ubiquitination and degradation, thereby enhancing NRF2 expression