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Measure whether daily maternal administration of vitamin B 12 from early pregnancy until 6 months postpartum affects heart rate variability
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Yet, the startling reality is that metabolic and nutritional factors, many of which are modifiable, are now recognized as primary drivers of its pathogenesis, contributing to a global burden that afflicts over 300 million people ( OA stands as the most common chronic joint disease and a leading cause of disability globally ( Capitalizing on this understanding, nutritional interventions target OA through a multi-tiered approach: (1) Upstream regulation using anti-inflammatory nutrients (e.g., omega-3 fatty acids, polyphenols) to quell systemic inflammation and oxidative stress ( As the evidence base solidifies, the future of OA care lies in personalization, tailoring nutritional plans based on genetics, gut microbiota, and individual metabolic profiles
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