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429 CHOP deletion has been shown to have cytoprotective effects in multiple mouse models of diseases characterized by constitutive ER stress and UPR activation, 445,450 suggesting that it may be an important transducer of proapoptotic UPR signaling in several contexts

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Synergies with other metabolic peptides While GLP-1–based peptides primarily influence insulin and glucose secretion, amylin analogues like cagrilintide contribute distinct satiety and gastric-emptying signals