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In spinal cord injury and traumatic brain injury models, Tβ4 treatment significantly improved locomotor and sensorimotor functional recovery and spatial learning, as well as increased survival of neurons and OLs, and reduced cortical lesion volumes after neurological injuries (Cheng et al., 2014, Xiong et al., 2012)

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This is because they generally act on more lipid-soluble (nonpolar) substrates, and their purpose is to make the compounds MORE POLAR and therefore, MORE EASILY EXCRETABLE by the kidney and biliary tract