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These intermediates are stabilized through H-bonds between their ribosyl 2′-, 3′- OH groups and the catalytic residue Glu226, a residue required for the NADase and cyclase activity of the enzyme [38-40, 58-60]

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By simultaneously increasing the rate of fat breakdown while decreasing the rate of new fat formation, AOD9604 creates a net catabolic effect on adipose tissue stores