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Specifically, mice were gavaged with IPA at 200 mg/kg (insoluble, suspend thoroughly before gavage, 200 μL PBS per mouse) daily 36 , or at a lower dose of 20 mg/kg (solution, 0.5 mg per 200 μL PBS) daily for 5 days 37,38

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Overall, these findings provide substantial evidence for the role of ROS in inducing apoptotic cell death, establishing that ROS are as a promising pathway in tumor therapy