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Moreover, because much of the DHA detected in tissues is probably localized in the apoplast rather than the cytosol, we can assume that plant cells are able to maintain very high cytoplasmic ascorbate-DHA ratios simultaneously with low GSH-GSSG ratios, presumably because of efficient GSH-independent pathways of ascorbate regeneration and/or the difference in redox potential between the GSH/GSSG and ascorbate/DHA couples (Fig

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Both require further human clinical trials to fully establish their therapeutic potential, though GHK-Cu's existing commercial use in dermatology provides some real-world validation of its skin-related applications