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Keywords: Adrenal gland, Cortisol, Epinephrine, Hypothyroidism, Vitamin B12 Introduction The adrenal glands are key organs in the endocrine system that play crucial roles in the hormonal regulation of immune responses (Pignatti and Flück, 2021) as the cortex secretes steroid hormones that regulate body homeostasis in response to chronic stress, while the medulla synthesizes epinephrine and norepinephrine that modulate acute stress response (Connell and Davies, 2005)

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Using a combination of X-ray crystallography and LO-NMR methods, we identified fragments binding in both the leucine and phenylalanine binding pockets of the TIN2 binding site, two sites crucial for TIN2 TBM engagement with TRF1 TRFH through the F-X-L-X-P motif 15