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This dose-dependent paradox presents a major challenge for the clinical application of aspirin in hearing protection

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This notion warrants further investigation to understand not only the physiological role of HCAR1 but also its potential therapeutic role in brain pathology, as for instance, it has been proposed that HCAR1 mediates the lactate‐mediated neuroprotection after acute neonatal hypoxia‐ischemia injury (Kennedy et al