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A mechanistic study on lung adenocarcinoma found that Stenotrophomonas maltophilia can upregulate the expression of histone deacetylase 5 (HDAC5) gene, inducing aberrant activation of the Apelin signaling pathway and thereby enhancing tumor cell migration (53)
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CRT further provides an ‘eat me’ signal and increases the local neoantigen level for uptake by DC
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