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the patients who received placebo only lost 2.4% of their excess body weight – a 12.5% difference in lost body weight between treated and non-treated patients Semaglutide weight loss mechanism #2: it controls appetite and promotes satiety Semaglutide limits appetite and promotes feelings of satiety (fullness): “Peripherally administered GLP-1 also affects the central regulation of feeding

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Two GH pathways GHRH (tesamorelin) + ghrelin-receptor (ipamorelin)

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