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[14] initially tested the roles of NNMT in gluconeogenesis and found that NNMT knockdown decreases hepatocyte glucose output, glucose-6-phosphatase catalytic (G6pc) expression, and phosphoenolpyruvate carboxykinase 1 cytosolic ( Pck1 ) expression in primary hepatocytes

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The more recent STEP UP trial tested a higher dose of 7.2 mg and showed average weight loss of 20.7% at 72 weeks