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These studies have also offered valuable insights into the mechanisms underlying saponins’ interaction with cholesterol in these membrane models (Lorent J
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Further lipoyl bearing domains LBDs of the E2 core are attached serving as swing arms impart substrate chanelling by sequentially visiting the different active sites in each of the three E1, E2 and E3 catalytic components [51] to transfer acyl groups to the active site of E2 leading to oxidative decarboxylation of the alpha ketoacids [51].The complex has 3 main enzymatic components with multiple subunits & copies and varied names: oxoglutarate dehydrogenase (lipoamide)
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