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AOD-9604 activates GH receptors for lipolysis without triggering IGF-1 from the liver. That distinction matters for patients who need GH receptor signaling but must avoid IGF-1 elevation. It targets visceral adipose, insulin

doi: 10.3322/caac.21660 14

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Such systemic distribution underlies the wide spectrum of AEs, including myocarditis, hepatitis, ovarian dysfunction, and neuroinflammation