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By tuning the viscosity of condensates (108) and enhancing the adenosine moiety effect to protect protein hydration shells and prevent hydrophobic collapse often associated with amyloid fibrillization and aggregation (107), melatonin may be instrumental for the successful attenuation of AMD progression via the regulation of protein phase separation in the retina under normal and oxidative conditions

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Moreover, the authors emphasize that the sources of ROS extend beyond skeletal muscle to include blood and other organs, suggesting that a comprehensive, integrative approach is essential for a complete understanding of the underlying mechanisms [124]