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Taken together, Lambert and colleagues concluded that acrolein and other 2-alkenals found in cigarette smoke can disrupt physiological regulation of gene expression by direct modification of the DNA-binding domain of a transcription factor and, as a consequence, they may cause immunosuppression upon exposure via cigarette smoke

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7,8 The hypothalamic-pituitary-gonadal (HPG) axis is a complex system that regulates gonadal and sexual function