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These concerns were later addressed by using separate fibers for capillaries and venules and replacing astrocytes with human smooth muscle cells (Cucullo et al., Even with these advantages, DIV-BBB models were superseded by BBB-on-chip models based on nano-fabrication and microfluidic techniques (Ma et al., 2005)

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Curr Biol 18, 1118–1123, S0960-9822(08)00804-X 10.1016/j.cub.2008.06.047 [doi] (2008)

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